Two sample MR report

Telomere_length against aparc-DKTatlas rh volume cuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0690614	0.1344554	0.6128674
Weighted median	23	0.0422686	0.0608194	0.4870639
Inverse variance weighted	23	-0.0109134	0.0516028	0.8325057
Simple mode	23	-0.1334304	0.1354375	0.3352471
Weighted mode	23	0.0822351	0.0797566	0.3137075

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.42120	21	0.0114988
Inverse variance weighted	38.82506	22	0.0147772

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0035703	0.0075991	0.6433201

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011788	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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