Two sample MR report

Telomere_length against aparc-DKTatlas rh volume caudalmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1853069	0.1157056	0.1241944
Weighted median	23	-0.1090573	0.0594108	0.0664098
Inverse variance weighted	23	-0.0795474	0.0452008	0.0784301
Simple mode	23	-0.1953770	0.0926028	0.0464767
Weighted mode	23	-0.1337387	0.0730422	0.0806825

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.45256	21	0.1277769
Inverse variance weighted	29.78853	22	0.1236954

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0064936	0.0065394	0.3320158

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010298	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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