Two sample MR report

Telomere_length against aparc-DKTatlas rh volume caudalanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0881528	0.1105470	0.4341298
Weighted median	23	-0.0925712	0.0576051	0.1080551
Inverse variance weighted	23	-0.0290127	0.0425441	0.4952744
Simple mode	23	0.1058726	0.1189000	0.3828673
Weighted mode	23	-0.1207219	0.0737931	0.1160775

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.97050	21	0.207576
Inverse variance weighted	26.38823	22	0.235387

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0036312	0.0062479	0.5672991

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008165	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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