Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness transversetemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0014854	0.0994080	0.9882192
Weighted median	23	0.0281512	0.0550559	0.6091263
Inverse variance weighted	23	0.0062264	0.0388464	0.8726591
Simple mode	23	-0.0205109	0.0805005	0.8012502
Weighted mode	23	0.0070215	0.0682996	0.9190491

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.47256	21	0.4915307
Inverse variance weighted	20.47524	22	0.5533385

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0002911	0.0056183	0.9591683

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006212	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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