Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness supramarginal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1128542	0.0994059	0.2690468
Weighted median	23	-0.0857895	0.0551767	0.1199904
Inverse variance weighted	23	-0.0527860	0.0388454	0.1741864
Simple mode	23	-0.0914845	0.1020202	0.3795715
Weighted mode	23	-0.1142957	0.0679567	0.1067321

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.90319	21	0.8277778
Inverse variance weighted	15.33415	22	0.8475033

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0036882	0.0056182	0.5186502

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005206	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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