Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness superiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1436414	0.1061905	0.1905451
Weighted median	23	-0.0047455	0.0587112	0.9355783
Inverse variance weighted	23	-0.0225314	0.0419984	0.5916262
Simple mode	23	0.0796551	0.0990193	0.4297507
Weighted mode	23	-0.0491682	0.0692499	0.4851557

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.9648	21	0.2947672
Inverse variance weighted	25.7167	22	0.2640439

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0074362	0.0060017	0.229009

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007895	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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