Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness superiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1383614	0.1253606	0.2822072
Weighted median	23	-0.0094263	0.0608467	0.8768856
Inverse variance weighted	23	-0.0298218	0.0488597	0.5416260
Simple mode	23	0.0337611	0.1053485	0.7516356
Weighted mode	23	0.0219338	0.0893302	0.8083177

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.39919	21	0.0419739
Inverse variance weighted	34.80633	22	0.0405880

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0066644	0.0070852	0.3575985

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010725	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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