Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness superiorfrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1512486	0.1173797	0.2115737
Weighted median	23	0.0445691	0.0611075	0.4657849
Inverse variance weighted	23	0.0063833	0.0470311	0.8920379
Simple mode	23	0.1101000	0.1135235	0.3426672
Weighted mode	23	0.0148450	0.0864630	0.8652494

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.28181	21	0.1073985
Inverse variance weighted	32.24969	22	0.0732376

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0096787	0.0066341	0.159381

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000978	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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