Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness rostralmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1128753	0.1266168	0.3827770
Weighted median	23	0.0147309	0.0645842	0.8195781
Inverse variance weighted	23	0.0068867	0.0495418	0.8894436
Simple mode	23	-0.0260972	0.1098971	0.8144898
Weighted mode	23	0.0162388	0.0951096	0.8659907

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.07189	21	0.0356023
Inverse variance weighted	35.78506	22	0.0320157

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0073534	0.0071561	0.3158438

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010853	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8