Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness rostralanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1076104	0.1248848	0.3985980
Weighted median	23	-0.0069515	0.0595067	0.9070030
Inverse variance weighted	23	-0.0114109	0.0484687	0.8138757
Simple mode	23	-0.0491445	0.0996185	0.6266702
Weighted mode	23	-0.0532340	0.0637343	0.4125571

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.14498	21	0.0446340
Inverse variance weighted	34.25031	22	0.0463189

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0059066	0.0070582	0.4121008

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010405	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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