Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness precuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2025882	0.1045901	0.0663178
Weighted median	23	-0.0436861	0.0590861	0.4596864
Inverse variance weighted	23	-0.0457076	0.0423813	0.2808177
Simple mode	23	-0.0459311	0.1077828	0.6741429
Weighted mode	23	-0.0629277	0.0781475	0.4292975

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.24860	21	0.3308683
Inverse variance weighted	26.18829	22	0.2436856

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0096326	0.0059112	0.1181104

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008355	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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