Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness precentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2150721	0.1333757	0.1217751
Weighted median	23	0.0055726	0.0600321	0.9260414
Inverse variance weighted	23	-0.0159488	0.0540171	0.7677998
Simple mode	23	0.0549604	0.1029022	0.5986264
Weighted mode	23	-0.0130236	0.0773925	0.8679004

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.80681	21	0.0135768
Inverse variance weighted	42.54276	22	0.0053695

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0122262	0.0075381	0.11974

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012942	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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