Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness posteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0265712	0.1174801	0.8232516
Weighted median	23	0.0472074	0.0584523	0.4193072
Inverse variance weighted	23	0.0317101	0.0451618	0.4825893
Simple mode	23	0.0203134	0.0840621	0.8112917
Weighted mode	23	0.0406712	0.0557040	0.4730136

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.33063	21	0.1062874
Inverse variance weighted	29.73632	22	0.1250154

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0035785	0.0066397	0.5955909

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009212	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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