Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2305569	0.0994046	0.0305355
Weighted median	23	-0.1002628	0.0581135	0.0844745
Inverse variance weighted	23	-0.0428222	0.0388450	0.2702932
Simple mode	23	-0.1334025	0.1083162	0.2311007
Weighted mode	23	-0.1303522	0.0716741	0.0826011

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.43156	21	0.6846373
Inverse variance weighted	21.64117	22	0.4814728

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0115269	0.0056181	0.0528736

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006926	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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