Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness pericalcarine

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1985782	0.0994066	0.0588745
Weighted median	23	-0.0271539	0.0544738	0.6181487
Inverse variance weighted	23	0.0182427	0.0388457	0.6386262
Simple mode	23	-0.0488645	0.0909669	0.5965433
Weighted mode	23	-0.0408142	0.0540131	0.4578827

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	10.75835	21	0.9672886
Inverse variance weighted	16.37318	22	0.7969428

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0133127	0.0056182	0.0274676

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005028	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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