Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness parstriangularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0711051	0.0994075	0.4823077
Weighted median	23	0.0179120	0.0544238	0.7420640
Inverse variance weighted	23	-0.0002998	0.0388460	0.9938427
Simple mode	23	0.1217608	0.0933868	0.2057689
Weighted mode	23	0.0082611	0.0670265	0.9030276

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.50772	21	0.6166871
Inverse variance weighted	19.11667	22	0.6381134

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0043843	0.0056183	0.4438899

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005793	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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