Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness parsorbitalis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0497803	0.1006597	0.6260584
Weighted median	23	-0.0804912	0.0572026	0.1593906
Inverse variance weighted	23	-0.0878702	0.0388461	0.0236968
Simple mode	23	-0.1528288	0.1062808	0.1645156
Weighted mode	23	-0.1528288	0.0843687	0.0837486

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.53252	21	0.4268631
Inverse variance weighted	21.70580	22	0.4775616

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0023388	0.0056892	0.6851709

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008128	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8