Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness parsopercularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0528913	0.1009290	0.6057352
Weighted median	23	0.0354770	0.0574404	0.5368186
Inverse variance weighted	23	0.0610324	0.0388454	0.1161452
Simple mode	23	-0.0333986	0.1002392	0.7421458
Weighted mode	23	0.0131764	0.0712551	0.8549870

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.64833	21	0.4200123
Inverse variance weighted	21.65624	22	0.4805599

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004999	0.0057043	0.9310012

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000731	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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