Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness parahippocampal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1757780	0.0994148	0.0915665
Weighted median	23	0.0178753	0.0557280	0.7483929
Inverse variance weighted	23	0.0503299	0.0431214	0.2431431
Simple mode	23	0.0720239	0.1008235	0.4825186
Weighted mode	23	0.0047449	0.0594415	0.9370980

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.00367	21	0.458720
Inverse variance weighted	27.10987	22	0.207083

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0138828	0.0056186	0.0221257

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008724	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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