Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness paracentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2294327	0.0994044	0.0312687
Weighted median	23	-0.0156785	0.0604860	0.7954740
Inverse variance weighted	23	-0.0249321	0.0404014	0.5371618
Simple mode	23	-0.0030892	0.0970996	0.9749066
Weighted mode	23	-0.0030892	0.0760408	0.9679608

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.80314	21	0.5977671
Inverse variance weighted	23.79824	22	0.3578937

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0125564	0.0056181	0.0364143

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007336	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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