Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness middletemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0918228	0.1086500	0.4075677
Weighted median	23	0.1367554	0.0570358	0.0164979
Inverse variance weighted	23	0.0882488	0.0445684	0.0476952
Simple mode	23	0.1369639	0.0950144	0.1635256
Weighted mode	23	0.1085004	0.0683233	0.1265458

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.08746	21	0.2433958
Inverse variance weighted	28.96034	22	0.1459967

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0110563	0.0061406	0.0861603

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010339	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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