Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness medialorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0459944	0.1240673	0.7145586
Weighted median	23	0.0534680	0.0639056	0.4027777
Inverse variance weighted	23	0.0341352	0.0473801	0.4712453
Simple mode	23	0.0469291	0.1315623	0.7247099
Weighted mode	23	0.1260459	0.1564617	0.4290942

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.71405	21	0.0494856
Inverse variance weighted	32.73085	22	0.0657615

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0007282	0.0070121	0.9182786

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010152	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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