Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2292472	0.1072564	0.0444891
Weighted median	23	-0.0044047	0.0568698	0.9382638
Inverse variance weighted	23	0.0144065	0.0465103	0.7567520
Simple mode	23	-0.0134041	0.1049258	0.8995085
Weighted mode	23	-0.0284851	0.0632376	0.6567972

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.44828	21	0.2718490
Inverse variance weighted	31.53906	22	0.0856012

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0149602	0.0060619	0.0222655

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009599	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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