Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness lateralorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0003660	0.1244129	0.9976808
Weighted median	23	0.0682349	0.0568718	0.2302158
Inverse variance weighted	23	0.0186045	0.0475308	0.6954871
Simple mode	23	0.0851130	0.0991640	0.3999790
Weighted mode	23	0.0576251	0.0681207	0.4067005

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.89528	21	0.0473913
Inverse variance weighted	32.93826	22	0.0627475

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0011648	0.0070315	0.8700158

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001005	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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