Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness lateraloccipital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1651949	0.1077438	0.1401500
Weighted median	23	-0.0821319	0.0540966	0.1289525
Inverse variance weighted	23	-0.0540730	0.0423474	0.2016399
Simple mode	23	-0.0989961	0.0900391	0.2834458
Weighted mode	23	-0.0989961	0.0600510	0.1134519

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.67096	21	0.2616963
Inverse variance weighted	26.14580	22	0.2454747

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0068229	0.0060894	0.2751755

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008509	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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