Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness isthmuscingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0382724	0.1186578	0.7502296
Weighted median	23	-0.0337167	0.0547944	0.5383358
Inverse variance weighted	23	-0.0181750	0.0453386	0.6885145
Simple mode	23	0.0111400	0.0925000	0.9052334
Weighted mode	23	-0.0119428	0.0631013	0.8516218

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.92146	21	0.0935777
Inverse variance weighted	29.96970	22	0.1192028

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.001234	0.0067062	0.8557757

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009147	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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