Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness insula

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0315961	0.1635735	0.8486884
Weighted median	23	0.0092405	0.0581257	0.8736890
Inverse variance weighted	23	-0.0187310	0.0624613	0.7642677
Simple mode	23	-0.1029630	0.1109387	0.3634236
Weighted mode	23	0.0053923	0.0594208	0.9285144

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	56.86267	21	3.77e-05
Inverse variance weighted	56.88244	22	6.38e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0007899	0.0092446	0.9327175

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017305	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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