Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness inferiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0799258	0.1263168	0.5337330
Weighted median	23	-0.0305389	0.0613261	0.6185011
Inverse variance weighted	23	-0.0517869	0.0482940	0.2835736
Simple mode	23	-0.1026350	0.1136509	0.3762698
Weighted mode	23	0.0728680	0.1046714	0.4936187

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.91077	21	0.0370440
Inverse variance weighted	34.00535	22	0.0490628

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017277	0.0071392	0.8111219

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010841	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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