Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness inferiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0537968	0.1106924	0.6319982
Weighted median	23	0.0056382	0.0577088	0.9221697
Inverse variance weighted	23	-0.0155523	0.0424028	0.7137857
Simple mode	23	-0.0005176	0.0870579	0.9953098
Weighted mode	23	0.0069556	0.0735029	0.9254655

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.03945	21	0.2049490
Inverse variance weighted	26.21414	22	0.2426016

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0023482	0.0062561	0.7111668

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007991	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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