Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness fusiform

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2017281	0.1287269	0.1320368
Weighted median	23	-0.0341746	0.0601912	0.5701932
Inverse variance weighted	23	-0.0591127	0.0508138	0.2446993
Simple mode	23	-0.1050268	0.1030207	0.3190596
Weighted mode	23	-0.0776773	0.0737032	0.3033576

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.21710	21	0.0267242
Inverse variance weighted	37.64648	22	0.0200669

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0087565	0.0072753	0.2421393

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012108	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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