Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness entorhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0651200	0.1400275	0.6466808
Weighted median	23	-0.0340635	0.0595763	0.5674830
Inverse variance weighted	23	-0.0461350	0.0534887	0.3884020
Simple mode	23	-0.0393315	0.0831417	0.6408264
Weighted mode	23	-0.0358193	0.0603084	0.5586134

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.67003	21	0.0046282
Inverse variance weighted	41.71307	22	0.0067702

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0011657	0.007914	0.8843067

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013066	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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