Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness cuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1533208	0.1063656	0.1642041
Weighted median	23	-0.0509811	0.0580953	0.3801921
Inverse variance weighted	23	-0.0049740	0.0427714	0.9074212
Simple mode	23	-0.1333198	0.1008731	0.1998618
Weighted mode	23	-0.0681448	0.0673182	0.3224090

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.04355	21	0.2909532
Inverse variance weighted	26.67200	22	0.2239500

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0091084	0.0060115	0.1446388

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008087	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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