Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness caudalmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1055581	0.1239636	0.4040841
Weighted median	23	-0.0270820	0.0592304	0.6475047
Inverse variance weighted	23	-0.0101380	0.0481096	0.8331009
Simple mode	23	0.1177211	0.1144414	0.3148176
Weighted mode	23	0.0008420	0.0746575	0.9911035

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.65831	21	0.0501459
Inverse variance weighted	33.74582	22	0.0521249

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0058588	0.0070061	0.4124373

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010246	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8