Two sample MR report

Telomere_length against aparc-DKTatlas rh thickness caudalanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1211705	0.1230388	0.3359263
Weighted median	23	-0.1024181	0.0552505	0.0637816
Inverse variance weighted	23	-0.0180710	0.0478932	0.7059376
Simple mode	23	-0.0896848	0.0908540	0.3343113
Weighted mode	23	-0.0928936	0.0608970	0.1414027

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.17112	21	0.0562551
Inverse variance weighted	33.44064	22	0.0559386

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0063303	0.0069539	0.3729808

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010199	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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