Two sample MR report

Telomere_length against aparc-DKTatlas rh area transversetemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1922801	0.0994072	0.0666686
Weighted median	23	-0.0844632	0.0551357	0.1255436
Inverse variance weighted	23	-0.0446359	0.0388461	0.2505379
Simple mode	23	0.0843445	0.0980438	0.3989167
Weighted mode	23	-0.0982661	0.0681029	0.1631352

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.61643	21	0.8855046
Inverse variance weighted	16.21997	22	0.8048208

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0090654	0.0056183	0.1215528

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005315	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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