Two sample MR report

Telomere_length against aparc-DKTatlas rh area supramarginal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0102295	0.1453451	0.9445563
Weighted median	23	-0.0574425	0.0602620	0.3404820
Inverse variance weighted	23	-0.0461037	0.0557251	0.4080435
Simple mode	23	-0.1145135	0.1119925	0.3176524
Weighted mode	23	-0.0973129	0.0826247	0.2514724

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	44.89622	21	0.0017871
Inverse variance weighted	45.27526	22	0.0024484

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0034588	0.0082145	0.6779874

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014145	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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