Two sample MR report

Telomere_length against aparc-DKTatlas rh area superiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0396163	0.1121011	0.7273132
Weighted median	23	-0.0944644	0.0559262	0.0912023
Inverse variance weighted	23	-0.0600855	0.0428391	0.1607411
Simple mode	23	-0.0859094	0.0952820	0.3770169
Weighted mode	23	-0.0826126	0.0630627	0.2037078

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.70653	21	0.1807793
Inverse variance weighted	26.75658	22	0.2206182

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0012568	0.0063357	0.8446643

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008833	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8