Two sample MR report

Telomere_length against aparc-DKTatlas rh area superiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0735408	0.0994056	0.4676082
Weighted median	23	0.0667432	0.0559341	0.2327727
Inverse variance weighted	23	0.0080325	0.0388452	0.8361791
Simple mode	23	-0.1017072	0.1169008	0.3936778
Weighted mode	23	0.1056128	0.0763147	0.1802663

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.43764	21	0.4937121
Inverse variance weighted	20.95019	22	0.5238183

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0040222	0.0056182	0.4819226

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006361	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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