Two sample MR report

Telomere_length against aparc-DKTatlas rh area superiorfrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0252806	0.1205748	0.8359482
Weighted median	23	-0.0384632	0.0616026	0.5323801
Inverse variance weighted	23	-0.0543641	0.0465952	0.2433194
Simple mode	23	-0.0348700	0.1002295	0.7312210
Weighted mode	23	-0.0219582	0.0730297	0.7664853

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.89676	21	0.0753933
Inverse variance weighted	31.65440	22	0.0834820

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0048902	0.0068147	0.4809111

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010185	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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