Two sample MR report

Telomere_length against aparc-DKTatlas rh area rostralmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0178077	0.1251235	0.8881829
Weighted median	23	-0.0032084	0.0601338	0.9574491
Inverse variance weighted	23	-0.0577815	0.0482586	0.2311774
Simple mode	23	-0.0257924	0.0887686	0.7741109
Weighted mode	23	-0.0178314	0.0687044	0.7976328

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.27207	21	0.0432860
Inverse variance weighted	33.95451	22	0.0496498

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0046412	0.0070717	0.5187565

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010959	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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