Two sample MR report

Telomere_length against aparc-DKTatlas rh area rostralanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0455415	0.0994070	0.6515633
Weighted median	23	-0.0359509	0.0543964	0.5086732
Inverse variance weighted	23	-0.0269977	0.0388458	0.4870577
Simple mode	23	0.0000610	0.0862312	0.9994421
Weighted mode	23	-0.0333598	0.0608949	0.5893265

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.89617	21	0.4653004
Inverse variance weighted	21.52463	22	0.4885489

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0044539	0.0056182	0.4367862

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006668	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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