Two sample MR report

Telomere_length against aparc-DKTatlas rh area precuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1538230	0.1230353	0.2249668
Weighted median	23	-0.0488967	0.0632527	0.4395005
Inverse variance weighted	23	-0.0057760	0.0488475	0.9058737
Simple mode	23	-0.0128790	0.1055610	0.9040026
Weighted mode	23	-0.0447364	0.0824324	0.5927896

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.17112	21	0.0562550
Inverse variance weighted	34.78902	22	0.0407565

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00909	0.0069536	0.205267

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010548	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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