Two sample MR report

Telomere_length against aparc-DKTatlas rh area precentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0154912	0.1046013	0.8836786
Weighted median	23	-0.0075802	0.0554607	0.8912865
Inverse variance weighted	23	-0.0461225	0.0400317	0.2492597
Simple mode	23	-0.0195601	0.0848451	0.8198036
Weighted mode	23	-0.0195601	0.0613174	0.7527378

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.25211	21	0.3306849
Inverse variance weighted	23.36418	22	0.3814161

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018807	0.0059118	0.7535251

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007506	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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