Two sample MR report

Telomere_length against aparc-DKTatlas rh area posteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1172668	0.1400650	0.4118898
Weighted median	23	-0.0547838	0.0588497	0.3519004
Inverse variance weighted	23	-0.0785206	0.0563347	0.1633712
Simple mode	23	-0.1643922	0.0930017	0.0909925
Weighted mode	23	-0.0667122	0.0602210	0.2799174

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.69253	21	0.0045983
Inverse variance weighted	46.27093	22	0.0018248

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0120212	0.0079161	0.143781

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015257	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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