Two sample MR report

Telomere_length against aparc-DKTatlas rh area postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0465686	0.1135302	0.6858233
Weighted median	23	-0.0080804	0.0620560	0.8963994
Inverse variance weighted	23	-0.0538227	0.0433495	0.2143840
Simple mode	23	0.0057563	0.1218563	0.9627494
Weighted mode	23	0.0161263	0.0832659	0.8482096

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.39181	21	0.1582575
Inverse variance weighted	27.39810	22	0.1964950

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0004454	0.0064165	0.9453159

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008884	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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