Two sample MR report

Telomere_length against aparc-DKTatlas rh area pericalcarine

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0300766	0.1158547	0.7976958
Weighted median	23	-0.0142824	0.0607078	0.8140028
Inverse variance weighted	23	0.0108241	0.0442673	0.8068308
Simple mode	23	-0.0844832	0.1097818	0.4497481
Weighted mode	23	-0.0685339	0.1173984	0.5653115

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.52702	21	0.1258275
Inverse variance weighted	28.57130	22	0.1575121

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0011821	0.0065479	0.8584648

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008681	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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