Two sample MR report

Telomere_length against aparc-DKTatlas rh area parstriangularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0282244	0.1355230	0.8370303
Weighted median	23	-0.0460499	0.0572922	0.4215286
Inverse variance weighted	23	-0.0007628	0.0518081	0.9882523
Simple mode	23	0.0410843	0.1176720	0.7303020
Weighted mode	23	-0.0419418	0.0621888	0.5070658

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.03197	21	0.0097294
Inverse variance weighted	39.13233	22	0.0136273

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0017798	0.0076595	0.8185015

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011858	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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