Two sample MR report

Telomere_length against aparc-DKTatlas rh area parsorbitalis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0046394	0.1357458	0.9730589
Weighted median	23	0.0488120	0.0598455	0.4147095
Inverse variance weighted	23	0.0328090	0.0518890	0.5271962
Simple mode	23	0.0971743	0.1125831	0.3973760
Weighted mode	23	0.0897628	0.0797610	0.2725490

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.15896	21	0.0093949
Inverse variance weighted	39.25373	22	0.0131962

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017296	0.0076721	0.8238141

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001211	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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