Two sample MR report

Telomere_length against aparc-DKTatlas rh area parahippocampal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1318274	0.1014337	0.2078104
Weighted median	23	0.0032158	0.0553749	0.9536897
Inverse variance weighted	23	-0.0079511	0.0407405	0.8452644
Simple mode	23	-0.0364687	0.0901034	0.6895748
Weighted mode	23	-0.0120967	0.0627115	0.8488119

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.86526	21	0.4073101
Inverse variance weighted	24.19880	22	0.3368954

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0085823	0.0057328	0.1492565

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007345	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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