Two sample MR report

Telomere_length against aparc-DKTatlas rh area middletemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0527968	0.1015235	0.6084713
Weighted median	23	0.0161685	0.0607429	0.7901016
Inverse variance weighted	23	-0.0138603	0.0389209	0.7217554
Simple mode	23	-0.0853330	0.1186772	0.4796883
Weighted mode	23	0.0122490	0.0923184	0.8956510

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.90498	21	0.4050034
Inverse variance weighted	22.08606	22	0.4547622

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0023907	0.0057379	0.6811605

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006731	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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